The objective of necessary work to develop fast dissolving tablet of Dimenhydrinate to give fast release of drug using different super disintegrants which would disintegrate tablet rapidly in oral cavity. Twelve batches of dimenhydrinate fast dissolving tablets were prepared by direct compression method using crospovidone, sodium starch glycollate, croscarmellosesodium and low substituted Hydroxypropyl cellulose as super disintegrants in different concentration in order to achieve faster disintegration of tablet. Crospovidone was the key ingredient which gives less disintegration time as well as fast drug release effect. Different nine formulations were prepared by varying the concentration of Crospovidone as a superdisintegrant and Microcrystalline cellulose. These formulations were evaluated for parameters like hardness, disintegration time, in-vitro drug release study, wetting time, water absorption ratio, drug content and drug excipient compatibility study. In this study, the release profile depends on the concentration of Crospovidone. A 32 factorial design was applied to check the effect of varying the concentration of Microcrystalline cellulose (X1) and Crospovidone (X2) on the dependent variable i.e. disintegration time (sec), wetting time (sec), % friability (%) and in-vitro drug release (%). Regression analysis and analysis of variance were performed for dependent variables. The results of the F-statistics were used to select the most appropriate model. Formulation F9 was considered optimum which contained Crospovidone (28 mg) and Microcrystalline cellulose (80 mg). The studies indicate that the formulation F9 was effective in providing less disintegration time as well as fast in-vitro drug release.
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